The interaction between natural killer (NK) cell and dendritic cell (DC), two important cellular components of innate immunity,\nstarted to be elucidated in the last years. The crosstalk between NK cells and DC, which leads to NK cell activation, DC maturation,\nor apoptosis, involves cell-cell contacts and soluble factors. This interaction either in the periphery or in the secondary lymphoid\norgans acts as a key player linking innate and adaptive immune responses to microbial stimuli. This review focuses on the\nmechanisms of NK-DC interaction and their relevance in antimicrobial responses.We specifically aim to emphasize the ability of\nvarious microbial infections to differently influence NK-DC crosstalk thereby contributing to distinct adaptive immune response.
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